The amount of active bone marrow, where blood cells are produced, decreases. Therefore, fewer blood cells are produced. Nonetheless, the bone marrow can usually produce enough blood cells throughout life. Problems may occur when the need for blood cells is greatly increased—for example, when anemia or an infection develops or bleeding occurs. In such cases, bone marrow is less able to increase its production of blood cells in response to the body’s needs. A simple treatment should be a temporary high altitude stay every year. Another, more intensive way, is a weekly leg training with (high) resistance.